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Sleeve gastrectomy elevates GIP <t>and</t> <t>GLP-1</t> levels in both peripheral circulation and hippocampal tissue of AD mice (A) Representative IHC images of GIP and GLP-1 expression in the hippocampus (scale bars: 50 μm). (B) Quantification of GLP-1 immunoreactive areas in the hippocampus ( n = 3 per group). (C) Quantification of GIP immunoreactive areas in the hippocampus ( n = 3 per group). (D) Serum GLP-1 concentrations across groups ( n = 6 per group). (E) Serum GIP concentrations across groups ( n = 6 per group). Data are presented as mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 vs. WT sham group; # p < 0.05 vs. AD sham group.
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Sleeve gastrectomy elevates GIP <t>and</t> <t>GLP-1</t> levels in both peripheral circulation and hippocampal tissue of AD mice (A) Representative IHC images of GIP and GLP-1 expression in the hippocampus (scale bars: 50 μm). (B) Quantification of GLP-1 immunoreactive areas in the hippocampus ( n = 3 per group). (C) Quantification of GIP immunoreactive areas in the hippocampus ( n = 3 per group). (D) Serum GLP-1 concentrations across groups ( n = 6 per group). (E) Serum GIP concentrations across groups ( n = 6 per group). Data are presented as mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 vs. WT sham group; # p < 0.05 vs. AD sham group.
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Sleeve gastrectomy elevates GIP <t>and</t> <t>GLP-1</t> levels in both peripheral circulation and hippocampal tissue of AD mice (A) Representative IHC images of GIP and GLP-1 expression in the hippocampus (scale bars: 50 μm). (B) Quantification of GLP-1 immunoreactive areas in the hippocampus ( n = 3 per group). (C) Quantification of GIP immunoreactive areas in the hippocampus ( n = 3 per group). (D) Serum GLP-1 concentrations across groups ( n = 6 per group). (E) Serum GIP concentrations across groups ( n = 6 per group). Data are presented as mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 vs. WT sham group; # p < 0.05 vs. AD sham group.
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Sleeve gastrectomy elevates GIP <t>and</t> <t>GLP-1</t> levels in both peripheral circulation and hippocampal tissue of AD mice (A) Representative IHC images of GIP and GLP-1 expression in the hippocampus (scale bars: 50 μm). (B) Quantification of GLP-1 immunoreactive areas in the hippocampus ( n = 3 per group). (C) Quantification of GIP immunoreactive areas in the hippocampus ( n = 3 per group). (D) Serum GLP-1 concentrations across groups ( n = 6 per group). (E) Serum GIP concentrations across groups ( n = 6 per group). Data are presented as mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 vs. WT sham group; # p < 0.05 vs. AD sham group.
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Sleeve gastrectomy elevates GIP <t>and</t> <t>GLP-1</t> levels in both peripheral circulation and hippocampal tissue of AD mice (A) Representative IHC images of GIP and GLP-1 expression in the hippocampus (scale bars: 50 μm). (B) Quantification of GLP-1 immunoreactive areas in the hippocampus ( n = 3 per group). (C) Quantification of GIP immunoreactive areas in the hippocampus ( n = 3 per group). (D) Serum GLP-1 concentrations across groups ( n = 6 per group). (E) Serum GIP concentrations across groups ( n = 6 per group). Data are presented as mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 vs. WT sham group; # p < 0.05 vs. AD sham group.
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Sleeve gastrectomy elevates GIP <t>and</t> <t>GLP-1</t> levels in both peripheral circulation and hippocampal tissue of AD mice (A) Representative IHC images of GIP and GLP-1 expression in the hippocampus (scale bars: 50 μm). (B) Quantification of GLP-1 immunoreactive areas in the hippocampus ( n = 3 per group). (C) Quantification of GIP immunoreactive areas in the hippocampus ( n = 3 per group). (D) Serum GLP-1 concentrations across groups ( n = 6 per group). (E) Serum GIP concentrations across groups ( n = 6 per group). Data are presented as mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 vs. WT sham group; # p < 0.05 vs. AD sham group.
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Sleeve gastrectomy elevates GIP <t>and</t> <t>GLP-1</t> levels in both peripheral circulation and hippocampal tissue of AD mice (A) Representative IHC images of GIP and GLP-1 expression in the hippocampus (scale bars: 50 μm). (B) Quantification of GLP-1 immunoreactive areas in the hippocampus ( n = 3 per group). (C) Quantification of GIP immunoreactive areas in the hippocampus ( n = 3 per group). (D) Serum GLP-1 concentrations across groups ( n = 6 per group). (E) Serum GIP concentrations across groups ( n = 6 per group). Data are presented as mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 vs. WT sham group; # p < 0.05 vs. AD sham group.
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Sleeve gastrectomy elevates GIP <t>and</t> <t>GLP-1</t> levels in both peripheral circulation and hippocampal tissue of AD mice (A) Representative IHC images of GIP and GLP-1 expression in the hippocampus (scale bars: 50 μm). (B) Quantification of GLP-1 immunoreactive areas in the hippocampus ( n = 3 per group). (C) Quantification of GIP immunoreactive areas in the hippocampus ( n = 3 per group). (D) Serum GLP-1 concentrations across groups ( n = 6 per group). (E) Serum GIP concentrations across groups ( n = 6 per group). Data are presented as mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 vs. WT sham group; # p < 0.05 vs. AD sham group.
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Sleeve gastrectomy elevates GIP <t>and</t> <t>GLP-1</t> levels in both peripheral circulation and hippocampal tissue of AD mice (A) Representative IHC images of GIP and GLP-1 expression in the hippocampus (scale bars: 50 μm). (B) Quantification of GLP-1 immunoreactive areas in the hippocampus ( n = 3 per group). (C) Quantification of GIP immunoreactive areas in the hippocampus ( n = 3 per group). (D) Serum GLP-1 concentrations across groups ( n = 6 per group). (E) Serum GIP concentrations across groups ( n = 6 per group). Data are presented as mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 vs. WT sham group; # p < 0.05 vs. AD sham group.
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Image Search Results


Sleeve gastrectomy elevates GIP and GLP-1 levels in both peripheral circulation and hippocampal tissue of AD mice (A) Representative IHC images of GIP and GLP-1 expression in the hippocampus (scale bars: 50 μm). (B) Quantification of GLP-1 immunoreactive areas in the hippocampus ( n = 3 per group). (C) Quantification of GIP immunoreactive areas in the hippocampus ( n = 3 per group). (D) Serum GLP-1 concentrations across groups ( n = 6 per group). (E) Serum GIP concentrations across groups ( n = 6 per group). Data are presented as mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 vs. WT sham group; # p < 0.05 vs. AD sham group.

Journal: iScience

Article Title: Sleeve gastrectomy improves cognition by enhancing central ERK/CREB/BDNF pathway through increased GIP secretion

doi: 10.1016/j.isci.2026.116292

Figure Lengend Snippet: Sleeve gastrectomy elevates GIP and GLP-1 levels in both peripheral circulation and hippocampal tissue of AD mice (A) Representative IHC images of GIP and GLP-1 expression in the hippocampus (scale bars: 50 μm). (B) Quantification of GLP-1 immunoreactive areas in the hippocampus ( n = 3 per group). (C) Quantification of GIP immunoreactive areas in the hippocampus ( n = 3 per group). (D) Serum GLP-1 concentrations across groups ( n = 6 per group). (E) Serum GIP concentrations across groups ( n = 6 per group). Data are presented as mean ± SD. ∗ p < 0.05, ∗∗ p < 0.01 vs. WT sham group; # p < 0.05 vs. AD sham group.

Article Snippet: GLP-1 (glucagon-like peptide-1) , MedChemExpress , Cat# HY-P0014.

Techniques: Expressing

Combined GIP and GLP-1 treatment enhances ERK/CREB/BDNF pathway activation and reduces Tau phosphorylation in HT22 cells (A) Representative immunoblots of pTau, Tau, GIPR, GLP-1R, pTrkB, TrkB, pERK, ERK, pCREB, CREB, BDNF, and β-actin under five treatment conditions: NC (negative control), Aβ, Aβ + GLP-1, Aβ + GIP, and Aβ + GLP-1 + GIP. (B) pTau/Tau ratio ( n = 3 per group). (C) GLP-1R/β-actin ratio ( n = 3 per group). (D) GIPR/β-actin ratio ( n = 3 per group). (E) pERK/ERK ratio ( n = 3 per group). (F) pCREB/CREB ratio ( n = 3 per group). (G) pTrkB/TrkB ratio ( n = 3 per group). Data represent mean ± SD; ∗ p < 0.05, ∗∗∗∗ p < 0.0001 vs. NC; # p < 0.05, ### p < 0.001 vs. Aβ; & p < 0.05 vs. Aβ + GIP group.

Journal: iScience

Article Title: Sleeve gastrectomy improves cognition by enhancing central ERK/CREB/BDNF pathway through increased GIP secretion

doi: 10.1016/j.isci.2026.116292

Figure Lengend Snippet: Combined GIP and GLP-1 treatment enhances ERK/CREB/BDNF pathway activation and reduces Tau phosphorylation in HT22 cells (A) Representative immunoblots of pTau, Tau, GIPR, GLP-1R, pTrkB, TrkB, pERK, ERK, pCREB, CREB, BDNF, and β-actin under five treatment conditions: NC (negative control), Aβ, Aβ + GLP-1, Aβ + GIP, and Aβ + GLP-1 + GIP. (B) pTau/Tau ratio ( n = 3 per group). (C) GLP-1R/β-actin ratio ( n = 3 per group). (D) GIPR/β-actin ratio ( n = 3 per group). (E) pERK/ERK ratio ( n = 3 per group). (F) pCREB/CREB ratio ( n = 3 per group). (G) pTrkB/TrkB ratio ( n = 3 per group). Data represent mean ± SD; ∗ p < 0.05, ∗∗∗∗ p < 0.0001 vs. NC; # p < 0.05, ### p < 0.001 vs. Aβ; & p < 0.05 vs. Aβ + GIP group.

Article Snippet: GLP-1 (glucagon-like peptide-1) , MedChemExpress , Cat# HY-P0014.

Techniques: Activation Assay, Phospho-proteomics, Western Blot, Negative Control